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Practical Challenges Multiple injections create significant burden: Injection fatigue: 2-7 injections weekly vs

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You cannot simply swap the pens

The FDA prescribing information for both Mounjaro and Zepbound does not list osteoporosis, bone loss, or fractures as known risks of the medication

Ectopic fat storage, insulin resistance, and hypertension

However, maximum effects require 45 weeks to reach steady-state drug levels, and significant outcomes develop gradually over months
