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Consistent with the proposed mechanism of action, systemic application of an 2 -adrenergic receptor agonist abolished the stimulatory effect of GLP-1 in the OB on insulin secretion

Munchies may still happen because THC can increase hunger, while CBD may counter some THC effects

Gallbladder disease cholelithiasis and cholecystitis have been reported, associated with the drug and with rapid weight loss

doi: 10.4102/jmh.v7i1.100

GLP-1 agonists affect diverse obesity etiopathogenic processes such as abnormal food intake regulation, adipocyte dysfunction, insulin resistance, adipokine production, inflammation, endothelial dysfunction, lipid metabolism, and oxidative stress

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