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Tirzepatide titration follows a specific protocol

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First 48 hours (acute phase): Cold compress only, 10 to 15 minutes every 2 to 3 hours Do not massage the area Ibuprofen 400mg every 6 hours if painful Keep the area elevated when possible (propping up with a pillow if the injection was in the thigh) After 48 hours (resolution phase): Switch from cold to warm compress Warm, damp cloth applied for 10 minutes, 3 to 4 times daily Warmth increases blood flow, accelerating absorption of the medication depot and clearing inflammatory debris Gentle massage is now acceptable, using light circular motions to help break up nodules Most lumps resolve completely within 7 to 10 days