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In the SURPASS-2 head-to-head against semaglutide for diabetes, tirzepatide produced significantly greater A1c reductions
However, this study failed to show a benefit of OCA in NASH resolution without fibrosis progression
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Am J Clin Nutr 1981
And it influences amino acid metabolism in ways that may help preserve lean muscle mass during weight loss, though this specific benefit requires more long-term data to confirm
