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Tirzepatide cardiovascular outcome data from the SURPASS-CVOT trial extends these findings to the dual agonist

Am J Surg 180(1):3336 Drucker DJ (2024) Efficacy and safety of GLP-1 medicines for type 2 diabetes and obesity

Distinguishing features that suggest inflammatory bowel conditions rather than expected Wegovy side effects include: Blood in stools (though some forms of colitis, such as microscopic colitis, typically present with persistent non-bloody diarrhoea) Persistent nocturnal diarrhoea disrupting sleep Severe, unremitting abdominal pain Unintentional weight loss beyond expected therapeutic effects Fever accompanying gastrointestinal symptoms Elevated inflammatory markers (CRP, ESR) or faecal calprotectin Progressive worsening rather than improvement over time Recognising these distinctions enables appropriate clinical decision-making regarding symptom management versus further investigation

If you have insurance that covers GLP-1s, PlushCare makes a lot of sense

[23] [13] Nausea is most common during the first week of GLP-1 therapy and typically improves significantly within 24 weeks as your body adjusts to the medication

Understanding which tier a peptide sits in helps set realistic expectations before the numbers are even discussed