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In addition to being more highly addictive, this excessive nicotine intake greatly disrupts brain function, leading to jitters, difficulty focusing, sleep issues, and irritability or even aggression
[DOI] [PMC free article] [PubMed] [Google Scholar] Cullen K
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2004, doi: 10.1007/s00213-003-1614-8 Leitzke, M., et al, "Long COVID a critical disruption of cholinergic neurotransmission?" Bioelectronic Medicine, Feb
