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These associations between cigarette exposure and global brain measures are consistent with prior studies of the effects of smoking on brain morphometry that did not control for alcohol use and cardiovascular disease [14, 23, 24], further establishing a robust association between cigarette exposure and widespread gray matter structural integrity and white matter hyperintensity volume

That matters because cardiovascular disease remains closely tied to smoking

Au contact de la nicotine, le cerveau libre de la dopamine (hormone du plaisir) et autres neurotransmetteurs apportant une sensation stimulante aux consommateurs

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But it has approved certain purified substances derived from marijuana (analogs)

1 2 "Smart & Final becomes private company"