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Phase I Block (Depolarizing Block) Activation of nACh receptors causes membrane depolarization Transient, random muscle fasciculations of varying duration and intensity occur in 94% of patients (Renew, 2026) 6) Continuous membrane depolarization causes inactivation of sodium channels The muscle membrane becomes unresponsive to acetylcholine within 1-2 minutes after i.v

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Previous studies have found that modulating the HPA axis can effectively alleviate PD-related depressive symptoms

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