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Cancer outcomes, mental health effects, and quality of life measures all factor into comprehensive evaluation of therapeutic value beyond scale weight changes

However, these studies found no significant improvements in a range of safety endpoints for cardiovascular diseases ( The Role of DPP-4 Inhibitors in Hypertension The first DPP-4 inhibitor, sitagliptin, was approved as an anti-hyperglycemic agent for T2DM in the United States of America in 2006

As a result, people who are overweight and obese can have a reduced risk of heart disease, diabetes, and certain cancers

All treatments were given in combination with metformin

When fatigue and muscle aches persist beyond a few days, worsen over time, or interfere with daily activities, they may indicate an underlying medical condition
