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Some patients may respond better to surgery than medication, especially if they have struggled with severe obesity for years and also have metabolic complications
Lactobacillus plantarum TWK10 improves muscle mass and functional performance in frail older adults: a randomized, double-blind clinical trial

doi:10.1038/cr.2010.178 45

The reasons are multifactorial: chronic inflammation damages blood vessel walls, corticosteroid use raises cholesterol and blood pressure, lupus-specific antibodies (particularly antiphospholipid antibodies) increase clotting risk, and the metabolic disruption caused by both the disease and its treatments creates a perfect storm for atherosclerosis

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The defendants produce internal documents, clinical trial data, safety reports, marketing materials, and communications about their GLP-1 drugs
