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In our cohort girls had significantly higher values for insulin, insulin resistance (HOMA IR and HOMA2-IR), lipid profile and total fat mass compared to boys This is in accordance with previous findings where girls had higher adiposity 14 and insulin resistance than boys 26 which was also found in this study when investigating the insulin sensitivity surrogate markers HOMA-IR and HOMA2-IR

It should be underlined that the beneficial effects resulting from even a 510% weight loss can be invalidated if there is a concomitant exaggerated loss of lean mass

Eur J Endocrinol 2020;183(5):R149-R166

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Create a structured side effect log that records the specific symptom, severity (mild/moderate/severe), timing relative to medication dose, duration, and any interventions attempted

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