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105 These findings imply that oxidized POLG causes mtDNA mutation or depletion and in turn results in a variety of diseases

Although these agents have been shown to be effective in vitro and in mice bearing drug-resistant human tumors, none thus far have been tested in clinical trials

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& Kirkham, M

If binding occurred with a low affinity for TfR, the level of BACE1 penetration through the BBB is increased [184, 185]

doi: 10.1128/jb.176.15.4664-4668.1994