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Although LCFAs have been reported to inhibit L-cell function through induction of endoplasmic reticulum stress or cell apoptosis 23,24 , the mitochondrial response in the L-cell dysfunction remains unknown

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Liver-targeting medications (such as resmetirom, fibroblast growth factor 21 analogs and lanifibranor), aiming at liver inflammation and collagen deposition, are expected to become crucial in individuals with more advanced liver disease [138]