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- **Naltrexone/Bupropion (Contrave)**: Influences hypothalamic appetite centers and the reward system to reduce cravings, with side effects like nausea, headache, and contraindication in seizure disorders

Compounded versions rely on pharmacy-specific stability studies and formulation protocols

CagriSema requires weekly injection of two combined peptides

People who are overweight or obese and those who exercise in a hot environment may sweat even more

While GLP-1 drugs are not yet covered by Medicare for weight loss, the government is considering a five-year pilot program to cover these medicines under Medicare and Medicaid to improve accessibility

This is because GLP-1 agonists can help counteract the physiological causes of weight regain, which can help reduce yo-yo weight cycling over time, Mitri adds