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SURMOUNT-1 showed average weight loss of 21.4% at 10mg over 72 weeks

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A study published in Clinical Therapeutics found that oral semaglutide was more cost-effective than injectable semaglutide in more than 50% of the model simulations, offering similar health benefits at a lower cost

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Future prospective studies are needed to quantify the efficacy and better understanding the cellular mechanisms of GLP-1 RAs on lymphedema

However, injection site reactions can be a problem for some people using GLP-1 agonists
