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The side effect profile of DPP-4 inhibitors is favorable, there are few treatment-limiting adverse effects and DPP-4 inhibitors have shown cardiovascular safety

And GLP-1 can inhibite hepatocyte apoptosis which induced by NLRP3 through autophagy in mitochondria, weakening the intrahepatic inflammatory response, thereby inhibiting the transition from simple fatty liver to nonalcoholic steatohepatitis (NASH)

120 Variations in genes related to bile acid metabolism, cholesterol transport, and gallbladder motility can significantly influence susceptibility

This reduces appetite, leading to lower calorie intake

B.et al (2017)