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Payers hesitation to cover GLP-1s for weight loss is also fueled by employer plan sponsor concerns about up-front costs of the drugs

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Nevertheless, the integration of two-year outcomes, rigorous propensity matching, millions of clinical notes analyzed through validated AI models, and one of the largest GLP-1RA-treated cohorts studied to date provides a robust characterization of real-world treatment heterogeneity

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The MafA-target gene PPP1R1A regulates GLP1R-mediated amplification of glucose-stimulated insulin secretion in -cells
