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Description
Unlike sulfonylureas or insulin, GLP-1 receptor agonists carry a low intrinsic risk of hypoglycemia when used as monotherapy

It may be possible in certain cases, but only with medical supervision

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10.1128/jb.183.19.5709-5717.2001 40 HuH.ShaoW.LiuQ.LiuN.WangQ.XuJ.et al (2022)
This sustained elevation in metabolic rate helps prevent the adaptive thermogenesis (metabolic slowdown) that typically accompanies significant weight loss and contributes to weight regain

Prior serious hypersensitivity to a GLP-1 medication