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Signal 22 (1), 113
Experimental models demonstrate that FOXO proteins mediate the inhibitory effects of insulin/IGF on target genes and are essential for maintaining metabolic homeostasis

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If the Phase 2a results hold, retatrutide could become the first truly effective pharmaceutical treatment for this condition

In addition, metformin contributes to a reduction in the risk of gynecologic malignancies, including ovarian, cervical, and endometrial cancers (Shi et al., 2019
