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The entire injection should take 15 to 20 seconds for volumes under 2mL, and 30 seconds or more for larger volumes

Christoffersen B, Sanchez-Delgado G, John LM, Ryan DH, Raun K, Ravussin E (2022) Beyond appetite regulation: targeting energy expenditure, fat oxidation, and lean mass preservation for sustainable weight loss

More concerning symptoms like severe vomiting, persistent abdominal pain, or signs of thyroid issues (rapid heartbeat, fatigue) warrant immediate medical evaluation

GLP-1 medications alone have robust safety data across thousands of patients

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A 2025 Vanderbilt study (Sharma RK et al, Otolaryngology-Head and Neck Surgery , PMID 40407186) measured facial volume in 20 patients on GLP-1 medications using CT and MRI imaging and documented a median 9% decrease in total midfacial volume (interquartile range 3% to 14%), with linear regression showing approximately 7% loss of midfacial volume per 10 kg of weight loss