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Another factor: newer drug formulations and biologics enter the market as injectables, and manufacturers tend to release pill versions later

This case occurred during a study in which the pills dosage was rapidly increased, and Pfizer stated that its decision was based on a thorough review of all clinical data and regulatory feedback

Hold the dose for another 4 weeks if side effects are still settling

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doi:10.1001/jama.293.4.455 Zhao K, Shkolnik, B, Lu J, Miller J, Schulsinger D