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A pilot open-label study by Sechi et al

L-Glutamine supports gut barrier repair and may help manage "leaky gut" in chronic conditions

If there's one molecule your body wishes it had more of, it's probably glutathione

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If needed for a clear medical indication (such as treating pellagra in a pregnant patient), niacinamide can be used with caution, but unnecessary high-dose B supplementation is avoided in pregnancy
For example, Vitamin C is essential for collagen production and skin repair, but it becomes "spent" once it neutralizes a free radical