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Eroglu C, Barres BA

Faccio G, Nivala O, Kruus K, Buchert J, Saloheimo M

This mechanism underpins both systemic analgesia and emerging strategies for local application, where NSAIDs incorporated into wound dressings or hydrogels can exert anti-inflammatory and analgesic effects directly at the site of tissue injury

Lee HY, Lee GH, Kim DS, et al

2024;283(Pt 2):137846

Preclinical data presented in a conference abstract demonstrated AG-946's ability to normalize levels of glycolytic intermediates, decrease 2,3-DPG levels, and increase hemoglobin levels in a Townes HbSS mouse model, although it did not significantly affect ATP levels or degree of RBC sickling