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The First Three Months Weight reduction typically becomes noticeable during this period, though the pace varies between individuals

Always check with a medical professional before making medical decisions

Weight loss with semaglutide GLP-1 typically occurs gradually as appetite suppression and improved metabolic regulation begin influencing daily habits

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Other GLP-1 medications remain under patent: Eli Lilly's medications (Mounjaro and Zepbound): Tirzepatide works differently from semaglutide, targeting both GLP-1 and GIP receptors rather than GLP-1 alone

Targeting GLP-1R expressed on microglia by NLY01 selectively inhibits microglial activation and induction of the reactive astrocyte inducers TNF-, C1q, and IL-1, thus protecting both mouse (5xFAD and 3xTg-AD mice) and human neurons in vitro (human embryonic stem cell (hESC)-derived human cortical neurons) [159]