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A sensitized high-throughput screen identified a series of small molecule GLP-1R agonists that were optimized to promote endogenous GLP-1R signaling with nM potency

This necessitates rethinking food categories and product portfolios, highlighting the critical role of adaptability to evolving consumer behavior and preferences for sustained relevance
This creates a two-pronged stimulation, direct receptor binding plus cytokine-mediated amplification

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The first is by crossing the bloodbrain barrier, which is composed of tightly connected epithelial cells