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The international medical community lacks consensus about the antidote or antidotes with the best risk-benefit ratio

These were the endothelium damaging agents, i.e., alcohol [32] or lithium [31], bile duct occlusion (acute pancreatitis) [29], organs and vessels compression (intra-abdominal hypertension) [31]

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FR, due to its high expression in some tumor tissues, is a potential and an attractive therapeutic target for the development of various novel anti-cancer agents