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Description
GLP-1 receptor agonists mechanism of action mimics the naturally occurring GLP-1 in the body, which results in improved blood sugar control
In clinical trials, patients on semaglutide 2.4 mg lost an average of about 15% of their body weight over 68 weeks

We found that applying compound C (CC, 5 M), an AMPK blocker 27 , inhibited the GLP-1R-mediated reversal of OGD-induced pericyte-mediated constriction of coronary capillaries ( p = 6.4 10 4 at 15 pericytes in 4 hearts, hearts are the statistical unit, one-way ANOVA with dks test on final-minute values, Fig

GLP-1 also acts on -cells to secrete insulin, which is known to suppress glucagon (233)

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