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Worldwide trends in diabetes since 1980: A pooled analysis of 751 population-based studies with 4.4 million participants

Two things are worth keeping in mind: this was shown in mice and laboratory cells, not yet in humans, and it is a different pathway from the fiber-and-SCFA route below

These data are consistent with the T allele decreasing risk for T2D, as well as decreasing glucose and HbA1c levels, but slightly increasing the risk of smoking initiation (Supplementary Table 16)

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RL, XS, and LZ contributed to the data analysis and manuscript preparation

In a 2025 review, the authors describe this species as occupying an extraordinary niche in the human gut, and a model organism studied for its ability to modulate human health and gut microbiome structure.13 In animal studies, it has slowed the development and progression of diabetes , obesity , and irritable bowel disease .14 In human trials, it has helped participants reduce their BMI and improve their diabetic markers.12 Its effects on obesity and diabetes have been recreated in humans as well