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[DOI] [PMC free article] [PubMed] [Google Scholar] 4.Denver RJ, Bonett RM, Boorse GC

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DPP-IV activity is upregulated during inflammatory responses, and preclinical models of colitis have demonstrated that DPP-IV inhibitors reduced the expression of proinflammatory cytokines and improved histological outcomes (77)

The phase III EVOKE trial (NCT04777396) and EVOKE+ trial (NCT04777409) are evaluating semaglutide's effects on cognition and disease biomarkers