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Therapeutic strategies targeting ferroptosis have evolved from single-target interventions to multidimensional, synergistic approaches: direct inhibition of the System Xc - GSHGPX4 axis (e.g., Erastin targeting SLC7A11, RSL3 targeting GPX4) effectively induces ferroptosis

[PubMed] [Google Scholar] 294.Kinoshita, T., Nagai, H., Murate, T

A., Rath-Shambaugh, M

These enzymes produce metabolites with free radical capture antioxidant (RTA) activity, thus terminating phospholipid peroxidation and inhibiting ferroptosis

G., Sostelly A., Goteti S., Makarova N., Avbersek A., Guo W., Bostwick B., Mummery C

Notably, this peptide had no observable affinity for opioid compounds either but did bind ascorbic acid (Table 2)