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Brain iron accumulation in aging and neurodegenerative disorders

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In addition, vitamin D modulates key cellular pathways involved in apoptosis, immune surveillance, DNA repair, and epithelial barrier stability, hallmarks of gastrointestinal carcinogenesis [46] (Fig

Zinc acts as a nutraceutical substance to maintain the barrier function of the epithelium (141)

Intratumoral copper modulates pd-L1 expression and influences tumor immune evasion

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