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Conclusion Pleiotropic mechanisms influence the pathogenesis of MASLD/MASH and related co-morbidities

Larger, more rigorously designed studies are needed before these findings alter clinical practice, she said

[5] Studies with semaglutide demonstrate that people can lose over 10 kg(22 lbs) of fat mass, but they will also lose up to 7 kg (15 lbs) of muscle mass

And drugmakers are trying other ways to end compounding of the blockbuster drugs

doi: 10.1194/jlr.R075481 64 Martin-SeguraAAhmedTCasadome-PeralesAPalomares-PerezIPalomerEKerstensAet al

"When you stop these low doses of these drugs, we don't know what's going to happen." On average, people will lose significantly less weight than they would with the maximum dose of a brand name version of the drug, McGowan agrees