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Self-reported sleep-related impairment (PROMIS-SRI T -score) was significantly correlated with cancer-related fatigue (Figure 6B, r = 0.75, p = 1.28 10 29 )

They specifically pertain to the Gi/o group (Gi 1 , 2 , 3

In addition isoliquiritigenin has been shown to be a potent anti-oxidant which allows it to prevent cancers, such as colon cancers, induced by exposure to oxidizing chemicals

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Crucially, mitochondrial metabolism reprogramming is orchestrated by core regulatory pathways (such as the HIF axis, AMPK/mTOR signaling, and sirtuin-mediated deacetylation cascades), which collectively modulate pyruvate dehydrogenase (PDH) activity, ETC efficiency, and anaplerotic flux (56)

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