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Description
A comprehensive literature search was conducted across the PubMed, Embase, and Google Scholar databases for peer-reviewed articles published from inception through June 15, 2026, focusing on the landmark SURPASS, SURMOUNT, and SUMMIT trial programs, relevant cardiorenal post hoc analyses, emerging body recomposition trials, and real-world cohort-switching protocols
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This systematic review evaluates preclinical and clinical evidence on glucagon-like peptide-1 receptor agonists as potential treatments for substance use disorders

Recombinant CHO-K1 cells stably overexpress human glucagon-like peptide-1 receptor (GLP1R) on the surface and contain high levels of G protein Gs to couple with the receptor in downstream signaling pathways.

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