does semaglutide cause osteoporosis Effects of Glucagon-Like Peptide-1 receptor agonists on bone health in people living with obesity GLP-1 Agonists and Orthopedic Surgery:

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The result is that patients eat less, feel full faster, and lose weight at a rate that exceeds most other pharmacological interventions

A 2026 PMC review (PMC 12904723) characterized GLP-1 side effects as follows: GI events are the most prevalent but are "typically transient and dose-dependent." No new safety signals have been identified, and the National Institutes of Health (NIH) continues to fund long-term outcome studies have emerged from long-term data up to 5 years

It is also worth noting that glucagon receptor activation can raise heart rate and plasma glucose

and metabolism 19 (9), 12421251