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The mechanism is thought to involve binding of the peptide C terminus to the receptor extracellular domain, followed by insertion of the peptide N terminus into the pocket formed by the transmembrane helices and extracellular loops, instigating receptor activation and signalling 19

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Then, more measurable weight loss occurs in the first 2 to 3 months, and increases over 6 to 12 months (SURMOUNT-1)

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