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Background and aims: Women with gestational diabetes mellitus (GDM) have increased risk of insulin resistance, glucose intolerance, and low-grade systemic inflammation in the postpartum

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This is primarily due to these medications lower effectiveness when compared to other, newer GLP-1s

We therefore sought to leverage an injectable hydrogel platform generated through self-assembly of dynamic, entropically-driven supramolecular interactions between biodegradable nanoparticles (NPs) and hydrophobically-modified hydroxypropyl methylcellulose (HPMC) derivatives to develop a long-acting GLP-1 RA formulation (Figure 1E) ( 3239 )

We do know that it happens more often in patients born with small optic discs (the front part of the optic nerve that can be seen within the eye)

Clinical trials have shown that patients on semaglutide lose an average of 15-22% of their body weight over 68 weeks, compared to 2-3% with placebo alone