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GIP is the main incretin hormone in healthy people, causative of most the incretin effects but the insulin response after GIP secretion in T2DM is reduced [12]

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Maintaining those lifestyle changes becomes a seamless process for lasting results

The titration protocol exists because GLP-1 receptor agonists cause gastrointestinal side effects, primarily nausea, that are dose-dependent

One study, completed in 2018, compared tirzepatide directly to dulaglutide: Results found that tirzepatide showed significantly better efficacy with regard to glucose control and weight loss than did dulaglutide, with an acceptable safety and tolerability profile. Side effects with tirzepatide were similar to those of dulaglutide and, in general, the drug was well tolerated