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(2025), in Diabetes, Obesity and Metabolism, reported a weighted mean difference of 1.02 kg in lean body mass across 19 RCTs

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This was the first pill-based GLP-1 medication approved in the US for weight management

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A 2023 study of more than 17,000 patients published in the New England Journal of Medicine found that semaglutide reduced the risk of major cardiovascular events including heart attack, stroke and cardiovascular death by about 20% in overweight or obese adults who already have cardiovascular disease but not diabetes