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For instance, after the initiation of retatrutidestill unapproved by the FDA but looking promising in Phase 3 trialspatients could receive nutritional guidance to preserve lean muscle and a skin care regimen to bolster recovery

At the same time, polyphenolspowerful antioxidants with anti-inflammatory benefitsare often under-consumed

Acting on GLP-1 and GIP receptors, retatrutide promotes delayed gastric emptying and sends hunger-reducing signals to the brain

Acetate helps support gut motility and promotes regularity

The upcoming SURMOUNT-MAINTAIN trial, expected to report results around mid-2026, will specifically compare the 5 mg maintenance dose against higher doses for weight maintenance after initial loss

tirzepatide, early research suggests that retatrutide may lead to the greatest average weight loss