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Key Points Tirzepatide (Mounjaro/Zepbound) works differently than semaglutide (Ozempic/Wegovy) by targeting two hormones instead of one Studies show tirzepatide typically leads to greater weight loss (15-20% vs 8-10%) and better blood sugar control than semaglutide Switching is generally straightforward you can finish your semaglutide dose and start tirzepatide about a week later on your normal dose day Most people start at a lower tirzepatide dose (2.5mg or 5mg) even if they were on a high dose of semaglutide Thinking about making the switch from semaglutide (Ozempic or Wegovy) to tirzepatide (Mounjaro or Zepbound)

Recognizing and Managing Overeating Signs While on Semaglutide Warning signs of overeating on semaglutide include persistent nausea lasting more than an hour after meals, severe abdominal discomfort, or a return of food to your mouth (regurgitation)

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Now, Wegovy itself is in short supply