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The triple-receptor approach: how retatrutide targets GLP-1, GIP, and glucagon Retatrutide takes a fundamentally different approach

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A C20 fatty diacid moiety, attached at position 17 via a gamma-glutamic acid and aminoethoxyethoxyacetic acid (AEEA) linker, extends the peptides half-life by promoting albumin binding, which slows clearance from the body

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