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Active ingredient in Zepbound and Mounjaro

Donors must meet fundamental requirements including weighing at least 50kg, being in good health on donation day, and having stable, well-controlled medical conditions

Nonetheless, the tirzepatide effect of delayed gastric emptying was found to significantly reduce oral contraceptive PK by ~ 60% and, thus, the drug label advises patients using oral hormonal contraceptives to switch to or add a non-oral contraceptive method when initiating tirzepatide and after each dose escalation

Malignancy Parks and Rosebrough first expressed concerns regarding human safety with liraglutide as early rodent trials demonstrated an increased risk of medullary thyroid carcinoma [199]

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