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Since vitamin B12 is primarily found in animal products, individuals following a plant-based diet may be at risk of deficiency

Vitamin B12 (B12) is an essential cofactor for two enzymes involved in onecarbon metabolism: methylmalonyl CoA mutase (reduced function of this enzyme results in increased serum methylmalonyl acid (MMA) levels) and methionine synthetase (this enzyme catalyzes the remethylmation of homocysteine to methionine)

10.1016/j.jcf.2014.08.008 41 CostelloC.Murphree-TerryM.OdenA.CombsS.KeithJ.BirketS

Once opened, mark the date on the vial and discard after 28 days regardless of appearance

Sikiric P., Seiwerth S., Rucman R., Drmic D., Stupnisek M., Kokot A., Sever M., Zoricic I., Zoricic Z., Batelja L., et al

[DOI] [PubMed] [Google Scholar] 118.Matson CA, Reid DF, Ritter RC