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A systematic review and meta-analysis of 35 trials showed that GLP-1 receptor agonists are associated with reductions in total and low-density lipoprotein cholesterol and triglyceride levels [68]

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This trial led the FDA to expand Wegovy's label to include reducing cardiovascular risk in people with obesity

Discussion Our findings demonstrate that GLP-1 receptor agonist-based therapeutics significantly disrupt the interoceptive stimulus effects of alcohol, highlighting a potential therapeutic mechanism through which these medications may reduce alcohol consumption and motivation

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