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Data were analyzed narratively to elucidate potential mechanisms and translational relevance

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The mouse models included lean mice (C57BL/6J and NSY.B6- a / a ), obese diabetic mice (NSY.B6- Ay / a ), proglucagon-deficient mice ( Gcg -/-), glucose-dependent insulinotropic polypeptide (GIP) receptor-deficient mice ( Gipr -/-), and ATP-sensitive potassium channel (KATP channel)-deficient mice ( Kcnj11 -/-)

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The study compared three types of the medication: tirzepatide (better known under the brand names Zepbound and Mounjaro), semaglutide (sold as Wegovy and Ozempic), and liraglutide (aka Saxenda and Victoza).