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GRP78, a central sensor of the UPR, binds unfolded proteins via its N-terminal domain and interacts with UPR signaling branches through its C-terminal domain, maintaining these pathways in an inactive state under basal conditions (Wu et al., 2015)

Improves skin texture, tone, and overall radiance

Even under normal levels of glutamate, mitochondrial dysfunction will increase the susceptibility of nigral neurons to glutamate excitotoxicity effects (85)

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Meyer et al., 2002b

Benefits should be balanced with risks such as hormonal disruption, side effects, lack of long-term safety data, and the risk of unregulated products, which require medical oversight and monitoring