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The weekly semaglutide or tirzepatide injectables for diabetes and weight loss are often hailed by patients for the major difference they can make

Injectable semaglutide affects the gut primarily through systemic GLP-1 receptor activation, while sublingual semaglutide and oral semaglutide drops also involve direct contact with the GI mucosa

Physiol Genomics (2005) 22:13949

doi: 10.1080/17474124.2017.1288096 12 CamilleriM.OduyeboI.HalawiH

Corticoids cause sodium retention that leads to a compensatory increase in urinary potassium excretion

Most patients report feeling fuller faster at meals and experiencing reduced cravings, particularly for sweets and high-fat foods