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That would be expected, given that obesity and excess weight are risk factors for heart attack and stroke

doi: 10.1111/dom.12382

Accordingly, weight loss is not clearly improved in studies with a high degree of SGLT2 inhibition (like canagliflozin 300 mg) compared to partial inhibition, for example with empagliflozin 10 mg

Nevertheless, GLP-1 RAs have gastrointestinal adverse effects such as abdominal pain, constipation, diarrhea, nausea, and vomiting [7]

Exenatide The FDA OKd exenatide in 2005, making it the first approved GLP-1 for Type 2 diabetes

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