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Description
Conversion of acetaminophen to the bioactive N-acylphenolamine AM404 via fatty acid amide hydrolase-dependent arachidonic acid conjugation in the nervous system
It has an oral phase, gastric digestion that includes the use of gastric lipase, and intestinal digestion, which allows analyzing the release of micronutrients and the digestion products (e.g., simple sugars, amino acids/peptides, fatty acids)
The underlying molecular mechanism involves the activation of CRH-1/CREB by CMK-1/CaMKI in AFD neurons, which in turn upregulates the FMRFamide neuropeptide (FLP-6) that acts on AIY interneurons [49] (Figure 1)
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10c,d), confirming there are functional organelles and substrates to produce and shuttle acetyl groups to and from carnitine in the extracts
